Annual Scientific Report 2014

Abstract

The major goal in the Martin group is to provide solutions to relevant and challenging synthetic problems from the scientific and industrial standpoint, without losing sight its environmental impact. In order to meet these challenges, the group is mainly focused on the metal-catalyzed, selective activation of relatively inert entities of great significance, such as CO₂, C-H bonds, C-C bonds and C-O bonds, as these motifs rank amongst the most widespread and fundamental linkages in organic chemistry. We are also interesting on the design and implementation of metal-catalyzed domino reactions since a high degree of molecular complexity can be achieved in a one-step, hence allowing a rapid access to key backbones occurring in many natural products.

Topics addressed

• Ni-catalyzed reductive cleavage of C-O Bonds
• Metal-catalyzed C-H bond-functionalization
• Ni-catalyzed CO₂ Activation

Articles

“Ligand-controlled regiodivergent Ni-catalyzed reductive carboxylation of allyl esters with CO₂”
J. Am. Chem. Soc. 2014, 136, 17702-17705
Moragas, T. ; Cornella, J. ; Martin, R.

“Metal-catalyzed activation of ethers via C-O bond-cleavage: a new strategy for molecular diversity”
Chem. Soc. Rev. 2014, 43, 8081-8097
Cornella, J.; Zarate, C.; Martin, R.

“Mild ArI-catalyzed C(sp²)-H or C(sp³)-H functionalization/C-O formation: an intriguing catalyst-controlled selectivity switch”
Angew. Chem. Int. Ed. 2014, 53, 11084-11087
Wang, X.; Gallardo-Donaire, J.; Martin, R.

“Ni-catalyzed reductive cleavage of methyl 3-methoxy-2-naphthoate”
Org. Synth. 2014, 91, 260-272
Cornella, J.; Zarate, C.; Martin, R.

“Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO₂”
J. Am. Chem. Soc. 2014, 136, 11212-11215
Liu, Y.; Cornella, J.; Martin, R.

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